SERPINE2, a Serine Protease Inhibitor Extensively Expressed in Adult Male Mouse Reproductive Tissues, May Serve as a Murine Sperm Decapacitation Factor1
نویسندگان
چکیده
منابع مشابه
Nematode sperm maturation triggered by protease involves sperm-secreted serine protease inhibitor (Serpin).
Spermiogenesis is a series of poorly understood morphological, physiological and biochemical processes that occur during the transition of immotile spermatids into motile, fertilization-competent spermatozoa. Here, we identified a Serpin (serine protease inhibitor) family protein (As_SRP-1) that is secreted from spermatids during nematode Ascaris suum spermiogenesis (also called sperm activatio...
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Bee venom is a rich source of pharmacologically active substances. In this study, we identified a bumblebee (Bombus ignitus) venom Kunitz-type serine protease inhibitor (Bi-KTI) that acts as a plasmin inhibitor. Bi-KTI showed no detectable inhibitory effect on factor Xa, thrombin, or tissue plasminogen activator. In contrast, Bi-KTI strongly inhibited plasmin, indicating that it acts as an anti...
متن کاملC1 inhibitor, a multi-functional serine protease inhibitor.
C1 inhibitor (C1INH) is a serpin that regulates both complement and contact (kallikrein-kinin) system activation. It consists of a serpin domain that is highly homologous to other serpins and an amino terminal non-serpin mucin-like domain. Deficiency of C1INH results in hereditary angioedema, a disease characterised by episodes of angioedema of the skin or the mucosa of the gastrointestinal tra...
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Understanding infertility and sterility requires knowledge of the molecular mechanisms underlying sexual reproduction. We have found that male mice deficient for the gene encoding the protease inhibitor protease nexin-1 (PN-1) show a marked impairment in fertility from the onset of sexual maturity. Absence of PN-1 results in altered semen protein composition, which leads to inadequate semen coa...
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Background: Heavy metals such as cadmium (Cd2+) are natural components of the Earth's crust which can not be degraded or destroyed. Industrial, mining and agricultural activities, particularly the excessive use of phosphate fertilizers, have led to high levels of cadmium contamination at many locations worldwide. Some toxic effects of cadmium are due to its inhibition of various enzyme sys...
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ژورنال
عنوان ژورنال: Biology of Reproduction
سال: 2011
ISSN: 0006-3363,1529-7268
DOI: 10.1095/biolreprod.110.085100